Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

Bo Hu, Gil Friedman, Eran Elinav, Richard A. Flavell

Research output: Contribution to journalArticlepeer-review


The microbiota is pivotal in orchestrating the pathogenesis of IBD-associated colorectal cancer (CRC). We recently demonstrated that altered elements in the microbiota of inflammasome-deficient mice drive transmissible inflammation-induced CRC. This microbiota-mediated effect is dependent upon microbiome-induced CCL5-driven inflammation, which, in turn, promotes epithelial cell proliferation through local activation of the IL-6 pathway, leading to cancer development.

Original languageEnglish
Article number981995
Number of pages3
Issue number10
Early online date7 May 2018
StatePublished - 3 Oct 2019


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