Translating solution to solid phase glycosylation conditions

Yasmeen Bakhatan, Dror Ben Abba Amiel, Yonatan Sukhran, Chieh Kai Chan, Wei Chih Lo, Po Wei Lu, Pin Hsuan Liao, Cheng Chung Wang, Mattan Hurevich

Research output: Contribution to journalArticlepeer-review

Abstract

Optimization of glycosylation conditions for automated glycan assembly is highly challenging, demands wasteful use of precious building blocks, and relies on nontrivial analyses. We developed a semi-quantitative method for automated optimization of glycosylation temperature that utilized minute quantities of donors and translated those conditions to solid-phase glycan assembly.

Original languageAmerican English
Pages (from-to)11256-11259
Number of pages4
JournalChemical Communications
Volume58
Issue number80
DOIs
StatePublished - 8 Sep 2022

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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