Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter; Alyssa B. Sargon; Jennifer B. Glass; Nicholas V. Hud; Loren Dean Williams

doi:10.1039/d0ra07965k

Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter, Alyssa B. Sargon, Jennifer B. Glass, Nicholas V. Hud, Loren Dean Williams

Research output: Contribution to journal › Article › peer-review

Abstract

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

Original language	English
Pages (from-to)	3534-3538
Number of pages	5
Journal	RSC Advances
Volume	11
Issue number	6
DOIs	https://doi.org/10.1039/d0ra07965k
State	Published - 18 Jan 2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1039/d0ra07965k

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title = "Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine",

abstract = "Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.",

author = "Moran Frenkel-Pinter and Sargon, \{Alyssa B.\} and Glass, \{Jennifer B.\} and Hud, \{Nicholas V.\} and Williams, \{Loren Dean\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = jan,

day = "18",

doi = "10.1039/d0ra07965k",

language = "الإنجليزيّة",

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T1 - Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

AU - Frenkel-Pinter, Moran

AU - Sargon, Alyssa B.

AU - Glass, Jennifer B.

AU - Hud, Nicholas V.

AU - Williams, Loren Dean

PY - 2021/1/18

Y1 - 2021/1/18

N2 - Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

AB - Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

UR - http://www.scopus.com/inward/record.url?scp=85100009776&partnerID=8YFLogxK

U2 - 10.1039/d0ra07965k

DO - 10.1039/d0ra07965k

M3 - مقالة

SN - 2046-2069

VL - 11

SP - 3534

EP - 3538

JO - RSC Advances

JF - RSC Advances

IS - 6

ER -

Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Abstract

All Science Journal Classification (ASJC) codes

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