Transition-Metal-Free Intermolecular α-Arylation of Ketones via Enolonium Species

Shimon Maksymenko, Keshaba N. Parida, Gulab K. Pathe, Atul A. More, Yuriy B. Lipisa, Alex M. Szpilman

Research output: Contribution to journalArticlepeer-review


Herein it is shown, for the first time, that enolonium species are powerful electrophiles capable of reacting with aromatic compounds in an intermolecular manner to afford α-arylated ketones. The reaction is compatible with a variety of functional groups, is of wide scope with respect to aromatic compounds and ketone, and even works for polymerization-prone substrates such as substituted pyrroles, thiophenes, and furans. Only 1.6 to 5 equiv of the commodity aromatic substrates is needed.

Original languageEnglish
Pages (from-to)6312-6315
Number of pages4
JournalOrganic Letters
Issue number23
StatePublished - 1 Dec 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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