TY - JOUR
T1 - Transforming parasites into their own foes
T2 - parasitic extracellular vesicles as a vaccine platform
AU - Alfandari, Daniel
AU - Cadury, Sharon
AU - Morandi, Mattia I.
AU - Regev-Rudzki, Neta
N1 - This work was generously supported by the Pasteur–Weizmann Delegation and the Dr Barry Sherman Institute for Medicinal Chemistry. N.R.R. is funded by the European Union (ERC, MalChemAtlas, 101086598 ). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. N.R.R. is supported by the Minerva Program support (grant number 714142 ), by the Israel Science Foundation (ISF) (grant No. 1637/20 ), within the Israel Precision Medicine Partnership (IPMP) program and the Israel Science Foundation (ISF; Grant Application no. 570/21 ).
PY - 2023/11
Y1 - 2023/11
N2 - Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.
AB - Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.
UR - https://www.scopus.com/pages/publications/85172161275
U2 - 10.1016/j.pt.2023.08.009
DO - 10.1016/j.pt.2023.08.009
M3 - Article
C2 - 37758631
SN - 1471-4922
VL - 39
SP - 913
EP - 928
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 11
ER -