Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Daniel Alfandari, Sharon Cadury, Mattia I. Morandi, Neta Regev-Rudzki

Research output: Contribution to journalArticlepeer-review

Abstract

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

Original languageEnglish
Pages (from-to)913-928
Number of pages16
JournalTrends in Parasitology
Volume39
Issue number11
Early online date25 Sep 2023
DOIs
StatePublished - Nov 2023

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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