TY - JOUR
T1 - Transforming parasites into their own foes
T2 - parasitic extracellular vesicles as a vaccine platform
AU - Alfandari, Daniel
AU - Cadury, Sharon
AU - Morandi, Mattia I.
AU - Regev-Rudzki, Neta
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023/11
Y1 - 2023/11
N2 - Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.
AB - Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.
UR - http://www.scopus.com/inward/record.url?scp=85172161275&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.pt.2023.08.009
DO - https://doi.org/10.1016/j.pt.2023.08.009
M3 - مقالة مرجعية
C2 - 37758631
SN - 1471-4922
VL - 39
SP - 913
EP - 928
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 11
ER -