Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa, Klaus H. Kaestner, Yuval Dor

Research output: Contribution to journalShort surveypeer-review

Abstract

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

Original languageAmerican English
Pages (from-to)809-811
Number of pages3
JournalCell Metabolism
Volume26
Issue number6
DOIs
StatePublished - 5 Dec 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Physiology
  • Cell Biology

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