Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa; Klaus H. Kaestner; Yuval Dor

doi:10.1016/j.cmet.2017.11.009

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa, Klaus H. Kaestner, Yuval Dor

Department of Developmental Biology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

Original language	English
Pages (from-to)	809-811
Number of pages	3
Journal	Cell Metabolism
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2017.11.009
State	Published - 5 Dec 2017

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2017.11.009

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abstract = "The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.",

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AB - The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

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Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Abstract

All Science Journal Classification (ASJC) codes

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