Transcriptional enhancers: Transcription, function and flexibility

Philippa Melamed; Yahav Yosefzon; Sergei Rudnizky; Lilach Pnueli

doi:10.1080/21541264.2015.1128517

Transcriptional enhancers: Transcription, function and flexibility

Philippa Melamed, Yahav Yosefzon, Sergei Rudnizky, Lilach Pnueli

Biology

Technion - Israel Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.

Original language	English
Pages (from-to)	26-31
Number of pages	6
Journal	Transcription
Volume	7
Issue number	1
DOIs	https://doi.org/10.1080/21541264.2015.1128517
State	Published - 1 Jan 2016

Keywords

chromatin
eRNA
enhancer
histone modification
non-coding RNA
promoter
transcription

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2015.1128517

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AU - Melamed, Philippa

AU - Yosefzon, Yahav

AU - Rudnizky, Sergei

AU - Pnueli, Lilach

PY - 2016/1/1

Y1 - 2016/1/1

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AB - Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.

KW - chromatin

KW - eRNA

KW - enhancer

KW - histone modification

KW - non-coding RNA

KW - promoter

KW - transcription

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U2 - 10.1080/21541264.2015.1128517

DO - 10.1080/21541264.2015.1128517

M3 - مقالة مرجعية

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VL - 7

SP - 26

EP - 31

JO - Transcription

JF - Transcription

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Transcriptional enhancers: Transcription, function and flexibility

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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