Transcription and splicing: When the Twain meet

Yehuda Brody; Yaron Shav-Tal

doi:10.4161/trns.2.5.17273

Transcription and splicing: When the Twain meet

Yehuda Brody, Yaron Shav-Tal

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Splicing can occur cotranscriptionally. What happens when the splicing reaction lags after the completed transcriptional process? We found that elongation rates are independent of ongoing splicing on the examined genes and suggest that when transcription has completed but splicing has not, the splicing machinery is retained at the site of transcription, independently of the polymerase.

Original language	English
Pages (from-to)	216-220
Number of pages	5
Journal	Transcription
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/trns.2.5.17273
State	Published - 2011

Keywords

Co-transcriptional splicing
Live-cell imaging
RNA polymerase
Transcription kinetics

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Genetics

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10.4161/trns.2.5.17273

Cite this

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title = "Transcription and splicing: When the Twain meet",

abstract = "Splicing can occur cotranscriptionally. What happens when the splicing reaction lags after the completed transcriptional process? We found that elongation rates are independent of ongoing splicing on the examined genes and suggest that when transcription has completed but splicing has not, the splicing machinery is retained at the site of transcription, independently of the polymerase.",

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author = "Yehuda Brody and Yaron Shav-Tal",

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AB - Splicing can occur cotranscriptionally. What happens when the splicing reaction lags after the completed transcriptional process? We found that elongation rates are independent of ongoing splicing on the examined genes and suggest that when transcription has completed but splicing has not, the splicing machinery is retained at the site of transcription, independently of the polymerase.

KW - Co-transcriptional splicing

KW - Live-cell imaging

KW - RNA polymerase

KW - Transcription kinetics

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DO - 10.4161/trns.2.5.17273

M3 - مقالة

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SP - 216

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JO - Transcription

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Transcription and splicing: When the Twain meet

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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