@inproceedings{dbddbfe1bee84933827b8ace0e9372d5,
title = "Towards personalized mental healthcare: An electrochemically-amplified biosensor for clozapine antipsychotic treatment monitoring",
abstract = "We present the first demonstration of a micro-scale electrochemically- amplifying biosensor for real-time monitoring of the antipsychotic clozapine. The amplification probe consists of a catechol-modified chitosan redox-cycling system, which increases the electrochemical signal generated by clozapine. Modified microelectrodes show a 2.5-fold higher clozapine oxidative current density compared to bare microelectrodes. Chitosan electrodeposition at the milli- and micro-scale yields deposition rates of 5.0±0.8 nm/s and 3.0±0.6 nm/s, respectively. Catechol grafting duration demonstrates positive correlation with the signal amplification, modeled using the oxidizing mediator ferrocenedimethanol. Moreover, the feasibility of the biosensor to distinguish 5, 25, and 50 μM of clozapine is successfully shown.",
keywords = "Antipsychotic clozapine, Biosensor, Electrochemical amplifier, Mental health, Redox-cycling",
author = "H. Ben-Yoav and Winkler, {T. E.} and Chocron, {S. E.} and Costa, {G. R.} and Restaino, {S. M.} and N. Woolsey and E. Kim and Kelly, {D. L.} and Payne, {G. P.} and R. Ghodssi",
year = "2013",
month = jan,
day = "1",
language = "American English",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
pages = "1167--1169",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}