Towards a Versatile Photoreactive Platform for Biosensing Applications

Kamal Elouarzaki, Oana Hosu, Karine Gorgy, Cecilia Cristea, Robert Sandulescu, Robert S. Marks, Serge Cosnier

Research output: Contribution to journalArticlepeer-review


An original interfacial hybrid cross-linker molecule combined electrochemical and photochemical properties by substitution of two functional groups, pyrene, and diazirine. The first group enables anchoring by strong π-stacking interaction or by electropolymerization onto multi-walled carbon nanotubes (MWCNT). The other photoreactive group allows the covalent link with biomolecules under long-wavelength UV illumination. Diazirine was chosen due to its ability to photogenerate high reactive radicals under UV irradiation. The photoreactivity of these immobilized nanostructured conductive surfaces was tested towards the covalent attachment of tyrosinase which is well known to oxidize a large range of phenolic compounds and its yield and availability was evaluated by amperometric measurements of catechol by using molecular dioxygen. The architecture exhibiting the best analytical characteristics obtained for catechol was then chosen to detect dopamine.

Original languageAmerican English
Article number16
JournalJournal of Analysis and Testing
Issue number2
StatePublished - 1 Apr 2017


  • Carbon nanotubes
  • Diazirine
  • Photoimmobilization
  • Tyrosinase

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Environmental Chemistry
  • Instrumentation
  • Spectroscopy
  • Electrochemistry
  • Materials Chemistry


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