Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Filip Senigl; Yaakov Maman; Ravi K. Dinesh; Jukka Alinikula; Rashu B. Seth; Lubomira Pecnova; Arina D. Omer; Suhas S.P. Rao; David Weisz; Jean Marie Buerstedde; Erez Lieberman Aiden; Rafael Casellas; Jiri Hejnar; David G. Schatz

doi:10.1016/j.celrep.2019.11.039

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz

Research output: Contribution to journal › Article › peer-review

Abstract

Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.

Original language	English
Pages (from-to)	3902-3915.e8
Journal	Cell Reports
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.11.039
State	Published - 17 Dec 2019
Externally published	Yes

Keywords

activation induced deaminase
chromatin loop extrusion
chromatin structure
somatic hypermutation
topologically associated domain
transcription factor

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.celrep.2019.11.039

Cite this

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title = "Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation",

abstract = "Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.",

keywords = "activation induced deaminase, chromatin loop extrusion, chromatin structure, somatic hypermutation, topologically associated domain, transcription factor",

author = "Filip Senigl and Yaakov Maman and Dinesh, {Ravi K.} and Jukka Alinikula and Seth, {Rashu B.} and Lubomira Pecnova and Omer, {Arina D.} and Rao, {Suhas S.P.} and David Weisz and Buerstedde, {Jean Marie} and Aiden, {Erez Lieberman} and Rafael Casellas and Jiri Hejnar and Schatz, {David G.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

day = "17",

doi = "10.1016/j.celrep.2019.11.039",

language = "الإنجليزيّة",

volume = "29",

pages = "3902--3915.e8",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "12",

}

TY - JOUR

T1 - Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

AU - Senigl, Filip

AU - Maman, Yaakov

AU - Dinesh, Ravi K.

AU - Alinikula, Jukka

AU - Seth, Rashu B.

AU - Pecnova, Lubomira

AU - Omer, Arina D.

AU - Rao, Suhas S.P.

AU - Weisz, David

AU - Buerstedde, Jean Marie

AU - Aiden, Erez Lieberman

AU - Casellas, Rafael

AU - Hejnar, Jiri

AU - Schatz, David G.

PY - 2019/12/17

Y1 - 2019/12/17

N2 - Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.

AB - Senigl et al. show that genome susceptibility to somatic hypermutation (SHM) is confined within topologically associated domains (TADs) and is linked to markers of strong enhancers and stalled transcription and high levels of the cohesin loader NIPBL. Insertion of an ectopic SHM targeting element renders an entire TAD susceptible to SHM.

KW - activation induced deaminase

KW - chromatin loop extrusion

KW - chromatin structure

KW - somatic hypermutation

KW - topologically associated domain

KW - transcription factor

UR - http://www.scopus.com/inward/record.url?scp=85076360673&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.11.039

DO - 10.1016/j.celrep.2019.11.039

M3 - مقالة

C2 - 31851922

SN - 2211-1247

VL - 29

SP - 3902-3915.e8

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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