TY - JOUR
T1 - Topographic Variations in Retinal Encoding of Visual Space
AU - Heukamp, Alina Sophie
AU - Warwick, Rebekah Anne
AU - Rivlin-Etzion, Michal
N1 - We thank William Grimes, Shai Sabbah, Noam Sobel, and members of the Rivlin lab for useful comments and discussions. The authors acknowledge support from the I-CORE (51/11), the Minerva Foundation, the ISF Foundation (1396/15), the European Research Council (ERC-StG 757732), Dr. and Mrs. Alan Leshner, the Lubin-Schupf Fund for Women in Science, the Charles and David Wolfson Charitable Trust, and Ms. Lois Pope. A.S.H. was supported by a Minerva doctoral fellowship. R.A.W. was supported by the Dean of Faculty fellowship at Weizmann Institute of Science. M.R.-E. is incumbent of the Sara Lee Schupf Family Chair.
PY - 2020/9/15
Y1 - 2020/9/15
N2 - A retina completely devoid of topographic variations would be homogenous, encoding any given feature uniformly across the visual field. In a naive view, such homogeneity would appear advantageous. However, it is now clear that retinal topographic variations exist across mammalian species in a variety of forms and patterns. We briefly review some of the more established topographic variations in retinas of different mammalian species and focus on the recent discovery that cells belonging to a single neuronal subtype may exhibit distinct topographic variations in distribution, morphology, and even function. We concentrate on the mouse retina-originally viewed as homogenous-in which genetic labeling of distinct neuronal subtypes and other advanced techniques have revealed unexpected anatomical and physiological topographic variations. Notably, different subtypes reveal different patterns of nonuniformity, which may even be opposite or orthogonal to one another. These topographic variations in the encoding of visual space should be considered when studying visual processing in the retina and beyond. Expected final online publication date for the Annual Review of Vision Science, Volume 6 is September 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
AB - A retina completely devoid of topographic variations would be homogenous, encoding any given feature uniformly across the visual field. In a naive view, such homogeneity would appear advantageous. However, it is now clear that retinal topographic variations exist across mammalian species in a variety of forms and patterns. We briefly review some of the more established topographic variations in retinas of different mammalian species and focus on the recent discovery that cells belonging to a single neuronal subtype may exhibit distinct topographic variations in distribution, morphology, and even function. We concentrate on the mouse retina-originally viewed as homogenous-in which genetic labeling of distinct neuronal subtypes and other advanced techniques have revealed unexpected anatomical and physiological topographic variations. Notably, different subtypes reveal different patterns of nonuniformity, which may even be opposite or orthogonal to one another. These topographic variations in the encoding of visual space should be considered when studying visual processing in the retina and beyond. Expected final online publication date for the Annual Review of Vision Science, Volume 6 is September 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
U2 - 10.1146/annurev-vision-121219-081831
DO - 10.1146/annurev-vision-121219-081831
M3 - مقالة
C2 - 32320630
SN - 2374-4642
VL - 6
SP - 237
EP - 259
JO - Annual Review of Vision Science
JF - Annual Review of Vision Science
ER -