To break or not to break–context matters

Karin Miron; Batsheva Kerem

doi:10.1080/23723556.2015.1072657

To break or not to break–context matters

Karin Miron, Batsheva Kerem

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

Original language	English
Article number	e1072657
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1072657
State	Published - 2 Jan 2016

Keywords

Cancer breakage
fragile sites
genome instability
oncogene expression
recurrent fragility
replication stress

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/23723556.2015.1072657

Cite this

@article{4af50d062e1a43039e715a368776773e,

title = "To break or not to break–context matters",

abstract = "Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.",

keywords = "Cancer breakage, fragile sites, genome instability, oncogene expression, recurrent fragility, replication stress",

author = "Karin Miron and Batsheva Kerem",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC.",

year = "2016",

month = jan,

day = "2",

doi = "10.1080/23723556.2015.1072657",

language = "الإنجليزيّة",

volume = "3",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - To break or not to break–context matters

AU - Miron, Karin

AU - Kerem, Batsheva

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

AB - Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

KW - Cancer breakage

KW - fragile sites

KW - genome instability

KW - oncogene expression

KW - recurrent fragility

KW - replication stress

UR - http://www.scopus.com/inward/record.url?scp=85032066014&partnerID=8YFLogxK

U2 - 10.1080/23723556.2015.1072657

DO - 10.1080/23723556.2015.1072657

M3 - مقالة

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - e1072657

ER -

To break or not to break–context matters

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Cite this