To break or not to break–context matters

Karin Miron, Batsheva Kerem

Research output: Contribution to journalArticlepeer-review

Abstract

Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

Original languageAmerican English
Article numbere1072657
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - 2 Jan 2016

Keywords

  • Cancer breakage
  • fragile sites
  • genome instability
  • oncogene expression
  • recurrent fragility
  • replication stress

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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