TMS motor mapping: Comparing the absolute reliability of digital reconstruction methods to the golden standard

Zeb D. Jonker; Rick van der Vliet; Christopher M. Hauwert; Carolin Gaiser; Joke H.M. Tulen; Jos N. van der Geest; Opher Donchin; Gerard M. Ribbers; Maarten A. Frens; Ruud W. Selles

doi:https://doi.org/10.1016/j.brs.2018.11.005

TMS motor mapping: Comparing the absolute reliability of digital reconstruction methods to the golden standard

Zeb D. Jonker, Rick van der Vliet, Christopher M. Hauwert, Carolin Gaiser, Joke H.M. Tulen, Jos N. van der Geest, Opher Donchin, Gerard M. Ribbers, Maarten A. Frens, Ruud W. Selles

Department of Biomedical Engineering

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Changes in transcranial magnetic stimulation motor map parameters can be used to quantify plasticity in the human motor cortex. The golden standard uses a counting analysis of motor evoked potentials (MEPs) acquired with a predefined grid. Recently, digital reconstruction methods have been proposed, allowing MEPs to be acquired with a faster pseudorandom procedure. However, the reliability of these reconstruction methods has never been compared to the golden standard. Objective: To compare the absolute reliability of the reconstruction methods with the golden standard. Methods: In 21 healthy subjects, both grid and pseudorandom acquisition were performed twice on the first day and once on the second day. The standard error of measurement was calculated for the counting analysis and the digital reconstructions. Results: The standard error of measurement was at least equal using digital reconstructions. Conclusion: Pseudorandom acquisition and digital reconstruction can be used in intervention studies without sacrificing reliability.

Original language	American English
Pages (from-to)	309-313
Number of pages	5
Journal	Brain Stimulation
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.brs.2018.11.005
State	Published - 1 Mar 2019

Keywords

Motor map
Reliability
Transcranial magnetic stimulation

All Science Journal Classification (ASJC) codes

Clinical Neurology
Biophysics
General Neuroscience

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https://doi.org/10.1016/j.brs.2018.11.005

Cite this

@article{6371e54d0b344b169ae00f11ae8df456,

title = "TMS motor mapping: Comparing the absolute reliability of digital reconstruction methods to the golden standard",

abstract = "Background: Changes in transcranial magnetic stimulation motor map parameters can be used to quantify plasticity in the human motor cortex. The golden standard uses a counting analysis of motor evoked potentials (MEPs) acquired with a predefined grid. Recently, digital reconstruction methods have been proposed, allowing MEPs to be acquired with a faster pseudorandom procedure. However, the reliability of these reconstruction methods has never been compared to the golden standard. Objective: To compare the absolute reliability of the reconstruction methods with the golden standard. Methods: In 21 healthy subjects, both grid and pseudorandom acquisition were performed twice on the first day and once on the second day. The standard error of measurement was calculated for the counting analysis and the digital reconstructions. Results: The standard error of measurement was at least equal using digital reconstructions. Conclusion: Pseudorandom acquisition and digital reconstruction can be used in intervention studies without sacrificing reliability.",

keywords = "Motor map, Reliability, Transcranial magnetic stimulation",

author = "Jonker, {Zeb D.} and {van der Vliet}, Rick and Hauwert, {Christopher M.} and Carolin Gaiser and Tulen, {Joke H.M.} and {van der Geest}, {Jos N.} and Opher Donchin and Ribbers, {Gerard M.} and Frens, {Maarten A.} and Selles, {Ruud W.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

month = mar,

day = "1",

doi = "https://doi.org/10.1016/j.brs.2018.11.005",

language = "American English",

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pages = "309--313",

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T1 - TMS motor mapping

T2 - Comparing the absolute reliability of digital reconstruction methods to the golden standard

AU - Jonker, Zeb D.

AU - van der Vliet, Rick

AU - Hauwert, Christopher M.

AU - Gaiser, Carolin

AU - Tulen, Joke H.M.

AU - van der Geest, Jos N.

AU - Donchin, Opher

AU - Ribbers, Gerard M.

AU - Frens, Maarten A.

AU - Selles, Ruud W.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Changes in transcranial magnetic stimulation motor map parameters can be used to quantify plasticity in the human motor cortex. The golden standard uses a counting analysis of motor evoked potentials (MEPs) acquired with a predefined grid. Recently, digital reconstruction methods have been proposed, allowing MEPs to be acquired with a faster pseudorandom procedure. However, the reliability of these reconstruction methods has never been compared to the golden standard. Objective: To compare the absolute reliability of the reconstruction methods with the golden standard. Methods: In 21 healthy subjects, both grid and pseudorandom acquisition were performed twice on the first day and once on the second day. The standard error of measurement was calculated for the counting analysis and the digital reconstructions. Results: The standard error of measurement was at least equal using digital reconstructions. Conclusion: Pseudorandom acquisition and digital reconstruction can be used in intervention studies without sacrificing reliability.

AB - Background: Changes in transcranial magnetic stimulation motor map parameters can be used to quantify plasticity in the human motor cortex. The golden standard uses a counting analysis of motor evoked potentials (MEPs) acquired with a predefined grid. Recently, digital reconstruction methods have been proposed, allowing MEPs to be acquired with a faster pseudorandom procedure. However, the reliability of these reconstruction methods has never been compared to the golden standard. Objective: To compare the absolute reliability of the reconstruction methods with the golden standard. Methods: In 21 healthy subjects, both grid and pseudorandom acquisition were performed twice on the first day and once on the second day. The standard error of measurement was calculated for the counting analysis and the digital reconstructions. Results: The standard error of measurement was at least equal using digital reconstructions. Conclusion: Pseudorandom acquisition and digital reconstruction can be used in intervention studies without sacrificing reliability.

KW - Motor map

KW - Reliability

KW - Transcranial magnetic stimulation

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TMS motor mapping: Comparing the absolute reliability of digital reconstruction methods to the golden standard

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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