Tissue engineering on the nanoscale: Lessons from the heart

Sharon Fleischer; Tal Dvir

doi:10.1016/j.copbio.2012.10.016

Tissue engineering on the nanoscale: Lessons from the heart

Sharon Fleischer, Tal Dvir

Biotechnology

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Recognizing the limitations of biomaterials for engineering complex tissues and the desire for closer recapitulation of the natural matrix have led tissue engineers to seek new technologies for fabricating 3-dimensional (3D) cellular microenvironments. In this review, through examples from cardiac tissue engineering, we describe the nanoscale hallmarks of the extracellular matrix that tissue engineers strive to mimic. Furthermore, we discuss the use of inorganic nanoparticles and nanodevices for improving and monitoring the performance of engineered tissues. Finally, we offer our opinion on the main challenges and prospects of applying nanotechnology in tissue engineering.

Original language	American English
Pages (from-to)	664-671
Number of pages	8
Journal	Current Opinion in Biotechnology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.copbio.2012.10.016
State	Published - 1 Aug 2013

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.copbio.2012.10.016

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title = "Tissue engineering on the nanoscale: Lessons from the heart",

abstract = "Recognizing the limitations of biomaterials for engineering complex tissues and the desire for closer recapitulation of the natural matrix have led tissue engineers to seek new technologies for fabricating 3-dimensional (3D) cellular microenvironments. In this review, through examples from cardiac tissue engineering, we describe the nanoscale hallmarks of the extracellular matrix that tissue engineers strive to mimic. Furthermore, we discuss the use of inorganic nanoparticles and nanodevices for improving and monitoring the performance of engineered tissues. Finally, we offer our opinion on the main challenges and prospects of applying nanotechnology in tissue engineering.",

author = "Sharon Fleischer and Tal Dvir",

note = "Funding Information: We acknowledge support from the European Union FP7 (CIG) program, and the Nicholas and Elizabeth Slezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University. We thank Brian Timko, Tzahi Cohen-Karni and Assaf Shapira for their useful comments.",

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AU - Dvir, Tal

N1 - Funding Information: We acknowledge support from the European Union FP7 (CIG) program, and the Nicholas and Elizabeth Slezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University. We thank Brian Timko, Tzahi Cohen-Karni and Assaf Shapira for their useful comments.

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N2 - Recognizing the limitations of biomaterials for engineering complex tissues and the desire for closer recapitulation of the natural matrix have led tissue engineers to seek new technologies for fabricating 3-dimensional (3D) cellular microenvironments. In this review, through examples from cardiac tissue engineering, we describe the nanoscale hallmarks of the extracellular matrix that tissue engineers strive to mimic. Furthermore, we discuss the use of inorganic nanoparticles and nanodevices for improving and monitoring the performance of engineered tissues. Finally, we offer our opinion on the main challenges and prospects of applying nanotechnology in tissue engineering.

AB - Recognizing the limitations of biomaterials for engineering complex tissues and the desire for closer recapitulation of the natural matrix have led tissue engineers to seek new technologies for fabricating 3-dimensional (3D) cellular microenvironments. In this review, through examples from cardiac tissue engineering, we describe the nanoscale hallmarks of the extracellular matrix that tissue engineers strive to mimic. Furthermore, we discuss the use of inorganic nanoparticles and nanodevices for improving and monitoring the performance of engineered tissues. Finally, we offer our opinion on the main challenges and prospects of applying nanotechnology in tissue engineering.

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DO - 10.1016/j.copbio.2012.10.016

M3 - Review article

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EP - 671

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 4

ER -

Tissue engineering on the nanoscale: Lessons from the heart

Abstract

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