TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration

Ron Goldner; Avraham Yaron

doi:10.1016/j.neuron.2017.03.005

TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration

Ron Goldner, Avraham Yaron

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Editorial › peer-review

Abstract

SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.

Original language	English
Pages (from-to)	1239-1241
Number of pages	3
Journal	Neuron
Volume	93
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2017.03.005
State	Published - 22 Mar 2017

All Science Journal Classification (ASJC) codes

General Neuroscience

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title = "TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration",

abstract = "SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.",

author = "Ron Goldner and Avraham Yaron",

note = "Israeli Science Foundation (ISF); U.S.-Israel Binational Science Foundation (BSF) Work in our laboratory is mainly funded by grants from the Israeli Science Foundation (ISF) and the U.S.-Israel Binational Science Foundation (BSF). A.Y. is an incumbent of the Jack & Simon Djanogly Professorial Chair in Biochemistry.",

year = "2017",

month = mar,

day = "22",

doi = "10.1016/j.neuron.2017.03.005",

language = "الإنجليزيّة",

volume = "93",

pages = "1239--1241",

journal = "Neuron",

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publisher = "Cell Press",

number = "6",

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TY - JOUR

T1 - TIR Axons Apart

T2 - Unpredicted NADase Controls Axonal Degeneration

AU - Goldner, Ron

AU - Yaron, Avraham

N1 - Israeli Science Foundation (ISF); U.S.-Israel Binational Science Foundation (BSF) Work in our laboratory is mainly funded by grants from the Israeli Science Foundation (ISF) and the U.S.-Israel Binational Science Foundation (BSF). A.Y. is an incumbent of the Jack & Simon Djanogly Professorial Chair in Biochemistry.

PY - 2017/3/22

Y1 - 2017/3/22

N2 - SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.

AB - SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.

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U2 - 10.1016/j.neuron.2017.03.005

DO - 10.1016/j.neuron.2017.03.005

M3 - كلمة العدد

SN - 0896-6273

VL - 93

SP - 1239

EP - 1241

JO - Neuron

JF - Neuron

IS - 6

ER -

TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration

Abstract

All Science Journal Classification (ASJC) codes

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