Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Ygal Rotenstreich; Inbal Sharvit-Ginon; Ifat Sher; Ofira Zloto; Ido Didi Fabian; Amir Abd-Elkader; Aron Weller; Anthony Heymann; Michal Schnaider Beeri; Ramit Ravona-Springer

doi:10.1002/dad2.12275

Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Ygal Rotenstreich, Inbal Sharvit-Ginon, Ifat Sher, Ofira Zloto, Ido Didi Fabian, Amir Abd-Elkader, Aron Weller, Anthony Heymann, Michal Schnaider Beeri, Ramit Ravona-Springer

Tel Aviv University, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

Original language	English
Article number	e12275
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12275
State	Published - 2022

Keywords

Alzheimer's disease
apolipoprotein E Ɛ4 genotype
high risk for Alzheimer's disease
offspring of Alzheimer's disease patients
optical coherence tomography
retinal biomarkers
retinal layers
retinal sectors

All Science Journal Classification (ASJC) codes

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12275

Cite this

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title = "Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk",

abstract = "Introduction: We compared retinal layers{\textquoteright} thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants{\textquoteright} mean age was 59.60 (standard deviation = 6.42) with 66.4\% women and 32.2\% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.",

keywords = "Alzheimer's disease, apolipoprotein E Ɛ4 genotype, high risk for Alzheimer's disease, offspring of Alzheimer's disease patients, optical coherence tomography, retinal biomarkers, retinal layers, retinal sectors",

author = "Ygal Rotenstreich and Inbal Sharvit-Ginon and Ifat Sher and Ofira Zloto and Fabian, \{Ido Didi\} and Amir Abd-Elkader and Aron Weller and Anthony Heymann and Beeri, \{Michal Schnaider\} and Ramit Ravona-Springer",

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year = "2022",

doi = "10.1002/dad2.12275",

language = "الإنجليزيّة",

volume = "14",

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T1 - Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

AU - Rotenstreich, Ygal

AU - Sharvit-Ginon, Inbal

AU - Sher, Ifat

AU - Zloto, Ofira

AU - Fabian, Ido Didi

AU - Abd-Elkader, Amir

AU - Weller, Aron

AU - Heymann, Anthony

AU - Beeri, Michal Schnaider

AU - Ravona-Springer, Ramit

PY - 2022

Y1 - 2022

N2 - Introduction: We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

AB - Introduction: We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P =.017), reaching statistical significance for the inner and outer nasal (P =.009 and P =.005, respectively), inner superior (P =.041), and inner and outer inferior (P =.013 and P =.033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P <.05) and the inner plexiform layer (P <.05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

KW - Alzheimer's disease

KW - apolipoprotein E Ɛ4 genotype

KW - high risk for Alzheimer's disease

KW - offspring of Alzheimer's disease patients

KW - optical coherence tomography

KW - retinal biomarkers

KW - retinal layers

KW - retinal sectors

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DO - 10.1002/dad2.12275

M3 - مقالة

C2 - 35155732

SN - 2352-8729

VL - 14

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12275

ER -

Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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