Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients

Kinjal Dasbiswas, Edouard Hannezo, Nir S. Gov

Research output: Contribution to journalArticlepeer-review


Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration-dependent manner?and whose spatial profile in turn is affected by cell shape. We map out theoretically the possible interplay between chemical concentration and cellular structure. Besides providing a direct route to spatial gradients in cell shape profiles in tissues, we show that the dependence on cell shape helps create robust mechanochemical gradients.
Original languageEnglish
Pages (from-to)968-977
Number of pages10
JournalBiophysical Journal
Issue number4
StatePublished - 27 Feb 2018

All Science Journal Classification (ASJC) codes

  • Biophysics


Dive into the research topics of 'Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients'. Together they form a unique fingerprint.

Cite this