The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

Naama Shoham, Natan T. Shaked, Dafna Benayahu, Amit Gefen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.

Original languageEnglish
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
Number of pages15
StatePublished - 2015

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials


  • Adipose Tissue
  • Brown Adipose Tissue
  • Magnetic Resonance Elastography
  • Subcutaneous Adipose Tissue
  • White Adipose Tissue

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials


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