The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Yelena Kravtsova-Ivantsiv; Aaron Ciechanover

doi:10.1080/23723556.2015.1054552

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Yelena Kravtsova-Ivantsiv, Aaron Ciechanover

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

Original language	English
Article number	e1054552
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2015.1054552
State	Published - 2 Oct 2015

Keywords

26S proteasome
KPC1
NF-κB
p105
tumor growth regulation
ubiquitin

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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10.1080/23723556.2015.1054552

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title = "The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression",

abstract = "The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.",

keywords = "26S proteasome, KPC1, NF-κB, p105, tumor growth regulation, ubiquitin",

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AU - Ciechanover, Aaron

PY - 2015/10/2

Y1 - 2015/10/2

N2 - The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

AB - The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

KW - 26S proteasome

KW - KPC1

KW - NF-κB

KW - p105

KW - tumor growth regulation

KW - ubiquitin

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M3 - مقالة

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VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - e1054552

ER -

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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