The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Yelena Kravtsova-Ivantsiv; Aaron Ciechanover

doi:10.1080/23723556.2015.1054552

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Yelena Kravtsova-Ivantsiv
, Aaron Ciechanover

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

Original language	English
Article number	e1054552
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2015.1054552
State	Published - 2 Oct 2015

Keywords

26S proteasome
KPC1
NF-κB
p105
tumor growth regulation
ubiquitin

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2015.1054552

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title = "The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression",

abstract = "The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50{\textendash}p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.",

keywords = "26S proteasome, KPC1, NF-κB, p105, tumor growth regulation, ubiquitin",

author = "Yelena Kravtsova-Ivantsiv and Aaron Ciechanover",

note = "Funding Information: Research in the laboratory of A.C. is supported by grants from the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF), the Israel Science Foundation (ISF), the I-CORE Program of the Planning and Budgeting Committee and the ISF (Grant1775/12), the EU Treat PolyQ Network, the Nobel Laureates Invitation Program of Seoul National University, the Deutsch-Israeli-sche Projektkooperation (DIP), and the Program for Targeting Cancer by Modulating Protein Dynamics supported by Albert Sweet, Malibu, CA, USA. A.C. is an Israel Cancer Research Fund (ICRF) USA Professor. Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 Taylor \& Francis Group, LLC.",

year = "2015",

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day = "2",

doi = "10.1080/23723556.2015.1054552",

language = "English",

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T2 - involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

AU - Kravtsova-Ivantsiv, Yelena

AU - Ciechanover, Aaron

N1 - Funding Information: Research in the laboratory of A.C. is supported by grants from the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF), the Israel Science Foundation (ISF), the I-CORE Program of the Planning and Budgeting Committee and the ISF (Grant1775/12), the EU Treat PolyQ Network, the Nobel Laureates Invitation Program of Seoul National University, the Deutsch-Israeli-sche Projektkooperation (DIP), and the Program for Targeting Cancer by Modulating Protein Dynamics supported by Albert Sweet, Malibu, CA, USA. A.C. is an Israel Cancer Research Fund (ICRF) USA Professor. Publisher Copyright: © 2015, © 2015 Taylor & Francis Group, LLC.

PY - 2015/10/2

Y1 - 2015/10/2

N2 - The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

AB - The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

KW - 26S proteasome

KW - KPC1

KW - NF-κB

KW - p105

KW - tumor growth regulation

KW - ubiquitin

UR - https://www.scopus.com/pages/publications/85046166882

U2 - 10.1080/23723556.2015.1054552

DO - 10.1080/23723556.2015.1054552

M3 - Article

SN - 2372-3556

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - e1054552

ER -

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

Abstract

Keywords

ASJC Scopus subject areas

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