BACKGROUND AND AIMS: We constructed the Toronto IBD Global Endoscopic Reporting [TIGER] score for inflammatory bowel disease [IBD]. The aim of our study was to develop and validate the TIGER score against faecal calprotectin [FC], C-reactive protein [CRP], and IBD Disk.
METHODS: A cross-sectional study was performed among 113 adult patients (60 Crohn's disease [CD] and 53 ulcerative colitis [UC]). In the development and usability phase, blinded IBD experts reviewed and graded ileocolonoscopy videos. In the validity phase the TIGER score was compared with:  the Simple endoscopic Score for CD [SES-CD] and the Mayo endoscopic score in CD and UC, respectively;  FC and CRP; and  IBD Disk.
RESULTS: Inter-observer reliability of the TIGER score per segment between reviewers was excellent: interclass correlation coefficient [ICC] = 0.94 [95% CI: 0.92-0.96]. For CD patients, overall agreement per segment between SES-CD and TIGER was 91% [95% CI: 84-95] with kappa coefficient 0.77 [95% CI: 0.63-0.91]. There was a significant correlation between TIGER and CRP [p <0.0083], and TIGER and FC [p <0.0001]. In addition, there was significant correlation between TIGER and IBD Disk [p <0.0001]. For UC patients, overall agreement per segment between Mayo endoscopic score and TIGER was 84% [95% CI: 74%-90%] and kappa coefficient 0.60 [95% CI: 0.42-0.808]. There was a significant correlation between TIGER and FC [p <0.0001]. There was a significant correlation between TIGER and IBD Disk [p <0.0001].
CONCLUSIONS: The TIGER score is a reliable and simple novel endoscopic score that can be used for both CD and UC patients and captures full endoscopic disease burden.
- C-Reactive Protein/metabolism
- Colitis, Ulcerative/diagnostic imaging
- Crohn Disease/diagnostic imaging
- Crohn's disease [CD]
- Crohn’s disease [CD]
- Cross-Sectional Studies
- Inflammatory Bowel Diseases/metabolism
- Inflammatory bowel diseases [IBD]
- Leukocyte L1 Antigen Complex/metabolism
- Reproducibility of Results
- Severity of Illness Index
- ulcerative colitis [UC]
All Science Journal Classification (ASJC) codes