The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Molhm Nassir; Abed Saady; Natalie Pariene Cohen; Bilha Fischer

doi:10.1002/cpz1.287

The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Molhm Nassir, Abed Saady, Natalie Pariene Cohen, Bilha Fischer

Department of Chemistry

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

Original language	English
Article number	e287
Journal	Current Protocols
Volume	1
Issue number	11
DOIs	https://doi.org/10.1002/cpz1.287
State	Published - Nov 2021

Keywords

DBU
cyclic phosphorothioate
nucleoside
nucleotides
thiophosphate

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
Health Informatics
Medical Laboratory Technology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1002/cpz1.287

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title = "The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity",

abstract = "This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.",

keywords = "DBU, cyclic phosphorothioate, nucleoside, nucleotides, thiophosphate",

author = "Molhm Nassir and Abed Saady and Cohen, \{Natalie Pariene\} and Bilha Fischer",

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doi = "10.1002/cpz1.287",

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AU - Saady, Abed

AU - Cohen, Natalie Pariene

AU - Fischer, Bilha

PY - 2021/11

Y1 - 2021/11

N2 - This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

AB - This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

KW - DBU

KW - cyclic phosphorothioate

KW - nucleoside

KW - nucleotides

KW - thiophosphate

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U2 - 10.1002/cpz1.287

DO - 10.1002/cpz1.287

M3 - مقالة

C2 - 34826354

SN - 1934-8525

VL - 1

JO - Current Protocols

JF - Current Protocols

IS - 11

M1 - e287

ER -

The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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