TY - JOUR
T1 - The synaptic basis for sexual dimorphism in the invertebrate nervous system
AU - Salzberg, Yehuda
AU - Haque, Rizwanul
AU - Oren-Suissa, Meital
N1 - We thank Hagar Setty for her assistance with the design of Figure 2. We thank members of the Oren-Suissa lab for their critical insights regarding the manuscript. MOS acknowledges financial support from the European Research Council ERC-2019-STG 850784, Israel Science Foundation grant 961/21, Dr. Barry Sherman Institute for Medicinal Chemistry, Sagol Weizmann-MIT Bridge Program and the Azrieli Foundation. MOS is the incumbent of the Jenna and Julia Birnbach Family Career Development Chair.
PY - 2023/10
Y1 - 2023/10
N2 - Many animal behaviors are manifested differently in the two sexes of a given species, but how such sexual dimorphism is imprinted in the nervous system is not always clear. One mechanism involved is synaptic dimorphism, by which the same neurons exist in the two sexes, but form synapses that differ in features such as anatomy, molecular content or fate. While some evidence for synaptic dimorphism exists in humans and mammals, identifying these mechanisms in invertebrates has proven simpler, due to their smaller nervous systems and absence of external regulation by sex hormones. This review aims to present the current status of the field in invertebrates, the available toolkit for the study of synaptic dimorphism, and the standing questions that still remain incompletely answered.
AB - Many animal behaviors are manifested differently in the two sexes of a given species, but how such sexual dimorphism is imprinted in the nervous system is not always clear. One mechanism involved is synaptic dimorphism, by which the same neurons exist in the two sexes, but form synapses that differ in features such as anatomy, molecular content or fate. While some evidence for synaptic dimorphism exists in humans and mammals, identifying these mechanisms in invertebrates has proven simpler, due to their smaller nervous systems and absence of external regulation by sex hormones. This review aims to present the current status of the field in invertebrates, the available toolkit for the study of synaptic dimorphism, and the standing questions that still remain incompletely answered.
UR - http://www.scopus.com/inward/record.url?scp=85167815410&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2023.102757
DO - 10.1016/j.conb.2023.102757
M3 - مقالة
C2 - 37572555
SN - 0959-4388
VL - 82
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
M1 - 102757
ER -