The role of the microbiome in NAFLD and NASH

Aleksandra A. Kolodziejczyk, Danping Zheng, Oren Shibolet, Eran Elinav

Research output: Contribution to journalReview articlepeer-review


Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of cardiometabolic syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly becoming the most prevalent liver disease worldwide. A sizable minority of NAFLD patients develop nonalcoholic steatohepatitis (NASH), which is characterized by inflammatory changes that can lead to progressive liver damage, cirrhosis, and hepatocellular carcinoma. Recent studies have shown that in addition to genetic predisposition and diet, the gut microbiota affects hepatic carbohydrate and lipid metabolism as well as influences the balance between pro-inflammatory and anti-inflammatory effectors in the liver, thereby impacting NAFLD and its progression to NASH. In this review, we will explore the impact of gut microbiota and microbiota-derived compounds on the development and progression of NAFLD and NASH, and the unexplored factors related to potential microbiome contributions to this common liver disease.

Original languageEnglish
Article numbere9302
Number of pages13
JournalEMBO Molecular Medicine
Issue number2
StatePublished - Feb 2019


  • microbiome/microbiota
  • nonalcoholic fatty liver disease
  • nonalcoholic steatohepatitis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine


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