Abstract
Phosphatidylinositol-transfer proteins (PITPs) have been initially identified as soluble factors that accelerate the monomeric exchange of either phosphatidylinositol (PI) or phosphatidylcholine (PC) between membrane bilayers in vitro. They are highly conserved in eukaryotes and have been implicated in different cellular processes, including vesicular trafficking, signal transduction, and lipid metabolism. Recent studies suggest that PITPs function at membrane contact sites (MCSs) to facilitate the transport of PI from its synthesis site at the endoplasmic reticulum (ER) to various membrane compartments. In this review, we describe the underlying mechanism of PITPs targeting to MCSs, discuss their cellular roles and potential mode of action.
| Original language | English GB |
|---|---|
| Pages (from-to) | 419-424 |
| Number of pages | 6 |
| Journal | Biochemical Society Transactions |
| Volume | 44 |
| Issue number | 2 |
| Early online date | 11 Apr 2016 |
| DOIs | |
| State | Published - 15 Apr 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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Keywords
- Lipid transfer
- Membrane contact sites
- PI-transfer proteins
- Phosphoinositides
- Signaling
ASJC Scopus subject areas
- Biochemistry
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