The plastic pancreas

Oren Ziv; Benjamin Glaser; Yuval Dor

doi:10.1016/j.devcel.2013.06.013

The plastic pancreas

Oren Ziv
, Benjamin Glaser
, Yuval Dor

Department of Developmental Biology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury conditions associated with inflammation. In parallel, it is becoming apparent that within the endocrine pancreas, hormone-producing cells can lose or switch their identity under metabolic stress or in response to single gene mutations. This new view of pancreas dynamics suggests interesting links between pancreas regeneration and pathologies including diabetes and pancreatic cancer.

Original language	English
Pages (from-to)	3-7
Number of pages	5
Journal	Developmental Cell
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2013.06.013
State	Published - 15 Jul 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Biology
General Biochemistry,Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2013.06.013

Cite this

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title = "The plastic pancreas",

abstract = "Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury conditions associated with inflammation. In parallel, it is becoming apparent that within the endocrine pancreas, hormone-producing cells can lose or switch their identity under metabolic stress or in response to single gene mutations. This new view of pancreas dynamics suggests interesting links between pancreas regeneration and pathologies including diabetes and pancreatic cancer.",

author = "Oren Ziv and Benjamin Glaser and Yuval Dor",

note = "Funding Information: We thank Christopher Wright, Klaus Kaestner, Ben Stanger, Lori Sussel and Doris Stoffers for stimulating discussions and comments. Research in our laboratories is funded by grants from the Beta-Cell Biology Consortium, the Juvenile Diabetes Research Foundation, the European Research Council, EU/FP7 (BetaCellTherapy, grant 241883), the Helmsley trust, the Dutch friends of Hebrew University, the Diabetes Onderzoek Nederland foundation, and the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation \#41.11. O.Z. is a New York Stem Cell Foundation-Druckenmiller Fellow.",

year = "2013",

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day = "15",

doi = "10.1016/j.devcel.2013.06.013",

language = "English",

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AU - Ziv, Oren

AU - Glaser, Benjamin

AU - Dor, Yuval

N1 - Funding Information: We thank Christopher Wright, Klaus Kaestner, Ben Stanger, Lori Sussel and Doris Stoffers for stimulating discussions and comments. Research in our laboratories is funded by grants from the Beta-Cell Biology Consortium, the Juvenile Diabetes Research Foundation, the European Research Council, EU/FP7 (BetaCellTherapy, grant 241883), the Helmsley trust, the Dutch friends of Hebrew University, the Diabetes Onderzoek Nederland foundation, and the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation #41.11. O.Z. is a New York Stem Cell Foundation-Druckenmiller Fellow.

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury conditions associated with inflammation. In parallel, it is becoming apparent that within the endocrine pancreas, hormone-producing cells can lose or switch their identity under metabolic stress or in response to single gene mutations. This new view of pancreas dynamics suggests interesting links between pancreas regeneration and pathologies including diabetes and pancreatic cancer.

AB - Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury conditions associated with inflammation. In parallel, it is becoming apparent that within the endocrine pancreas, hormone-producing cells can lose or switch their identity under metabolic stress or in response to single gene mutations. This new view of pancreas dynamics suggests interesting links between pancreas regeneration and pathologies including diabetes and pancreatic cancer.

UR - https://www.scopus.com/pages/publications/84880436692

U2 - 10.1016/j.devcel.2013.06.013

DO - 10.1016/j.devcel.2013.06.013

M3 - Review article

C2 - 23867225

SN - 1534-5807

VL - 26

SP - 3

EP - 7

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

The plastic pancreas

Abstract

UN SDGs

ASJC Scopus subject areas

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