The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM

Shahar Zirkin; Ateret Davidovich; Jeremy Don

doi:10.1074/jbc.M113.458851

The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM

Shahar Zirkin, Ateret Davidovich, Jeremy Don

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The PIM-2 kinase is a potent survival factor; its role in the DNA damage response has never been addressed. Results: PIM-2 promotes DNA lesions repair in an E2F-1 and ATM-dependent manner; Pim-2-silenced cells are more susceptible to UV damage. Conclusion: PIM-2 is an upstream activator of E2F-1 and ATM in the UV damage response. Significance: PIM-2 is an essential component of the UV damage response.

Original language	English
Pages (from-to)	21770-21783
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.458851
State	Published - 26 Jul 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/jbc.M113.458851

Cite this

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abstract = "Background: The PIM-2 kinase is a potent survival factor; its role in the DNA damage response has never been addressed. Results: PIM-2 promotes DNA lesions repair in an E2F-1 and ATM-dependent manner; Pim-2-silenced cells are more susceptible to UV damage. Conclusion: PIM-2 is an upstream activator of E2F-1 and ATM in the UV damage response. Significance: PIM-2 is an essential component of the UV damage response.",

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AB - Background: The PIM-2 kinase is a potent survival factor; its role in the DNA damage response has never been addressed. Results: PIM-2 promotes DNA lesions repair in an E2F-1 and ATM-dependent manner; Pim-2-silenced cells are more susceptible to UV damage. Conclusion: PIM-2 is an upstream activator of E2F-1 and ATM in the UV damage response. Significance: PIM-2 is an essential component of the UV damage response.

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The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM

Abstract

All Science Journal Classification (ASJC) codes

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