The physiological relevance of autophagosome morphogenesis

Oren Shatz; Zvulun Elazar

doi:10.1016/j.tibs.2024.05.002

The physiological relevance of autophagosome morphogenesis

Oren Shatz, Zvulun Elazar

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

Original language	English
Pages (from-to)	569-572
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	49
Issue number	7
DOIs	https://doi.org/10.1016/j.tibs.2024.05.002
State	Published Online - 24 May 2024

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

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10.1016/j.tibs.2024.05.002

Cite this

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title = "The physiological relevance of autophagosome morphogenesis",

abstract = "Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.",

author = "Oren Shatz and Zvulun Elazar",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

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AU - Elazar, Zvulun

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AB - Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

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U2 - 10.1016/j.tibs.2024.05.002

DO - 10.1016/j.tibs.2024.05.002

M3 - عرض مختصر

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SP - 569

EP - 572

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 7

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The physiological relevance of autophagosome morphogenesis

Abstract

All Science Journal Classification (ASJC) codes

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