The physiological relevance of autophagosome morphogenesis

Oren Shatz, Zvulun Elazar

Research output: Contribution to journalShort surveypeer-review


Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

Original languageEnglish
JournalTrends in Biochemical Sciences
StatePublished Online - 24 May 2024

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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