The Nucleolus as a Proteostasis Regulator

Fatima Amer-Sarsour; Avraham Ashkenazi

doi:https://doi.org/10.1016/j.tcb.2019.08.002

The Nucleolus as a Proteostasis Regulator

Fatima Amer-Sarsour, Avraham Ashkenazi

Cell and Developmental Biology

Tel Aviv University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

Original language	English
Pages (from-to)	849-851
Number of pages	3
Journal	Trends in Cell Biology
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.tcb.2019.08.002
State	Published - 1 Nov 2019

Keywords

chaperones
neurodegenerative diseases
nucleus
protein quality control

All Science Journal Classification (ASJC) codes

Cell Biology

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https://doi.org/10.1016/j.tcb.2019.08.002

Cite this

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title = "The Nucleolus as a Proteostasis Regulator",

abstract = "Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.",

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author = "Fatima Amer-Sarsour and Avraham Ashkenazi",

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year = "2019",

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doi = "https://doi.org/10.1016/j.tcb.2019.08.002",

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AU - Ashkenazi, Avraham

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AB - Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

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The Nucleolus as a Proteostasis Regulator

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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