The Nodes of Ranvier: Molecular Assembly and Maintenance

Matthew N. Rasband; Elior Peles

doi:https://doi.org/10.1101/cshperspect.a020495

The Nodes of Ranvier: Molecular Assembly and Maintenance

Matthew N. Rasband, Elior Peles

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

Original language	English
Article number	020495
Number of pages	15
Journal	Cold Spring Harbor perspectives in biology
Volume	8
Issue number	3
Early online date	15 Sep 2015
DOIs	https://doi.org/10.1101/cshperspect.a020495
State	Published - Mar 2016

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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https://doi.org/10.1101/cshperspect.a020495

Cite this

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title = "The Nodes of Ranvier: Molecular Assembly and Maintenance",

abstract = "Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).",

author = "Rasband, {Matthew N.} and Elior Peles",

note = "We thank Dr. Yael Eshed-Eisenbach for discussion and comments. Work performed in the authors{\textquoteright} laboratories is supported by the National Institutes of Health, NINDS Grants (NS50220 to E.P., NS044916 to M.N.R., and NS069688 to M.N.R.), the Israel Science Foundation, the United States – Israel Binational Science Foundation, the European Research Projects on Rare Diseases (E-Rare-2), the National Multiple Sclerosis Society, and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation. E.P. is the Incumbent of the Hanna Hertz Professorial Chair for Multiple Sclerosis and Neuroscience.",

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doi = "https://doi.org/10.1101/cshperspect.a020495",

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AU - Peles, Elior

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N2 - Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

AB - Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

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M3 - مقالة

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VL - 8

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

IS - 3

M1 - 020495

ER -

The Nodes of Ranvier: Molecular Assembly and Maintenance

Abstract

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