TY - JOUR
T1 - The neurexin superfamily of Caenorhabditis elegans
AU - Haklai-Topper, Liat
AU - Soutschek, Juergen
AU - Sabanay, Helena
AU - Scheel, Jochen
AU - Hobert, Oliver
AU - Peles, Elior
N1 - Shapell Family Biomedical Research Foundation; Moskowitz Center for Imaging at the Weizmann Institute; Israel Academy of Science; US-Israel Binational Science Foundation; Hanna Hertz Professorial ChairThis work was supported by grants from the Shapell Family Biomedical Research Foundation and the Moskowitz Center for Imaging at the Weizmann Institute, the Israel Academy of Science, and the US-Israel Binational Science Foundation. O.H. is an Investigator with the Howard Hughes Medical Institute. E.P. is the Incumbent of the Hanna Hertz Professorial Chair for Multiple Sclerosis and Neuroscience.
PY - 2011/1
Y1 - 2011/1
N2 - The neurexin superfamily is a group of transmembrane molecules mediating cell-cell contacts and generating specialized membranous domains in polarized epithelial and nerves cells. We describe here the domain organization and expression of the entire, core neurexin superfamily in the nematode Caenorhabditis elegans, which is composed of three family members. One of the superfamily members, nrx-1, is an ortholog of vertebrate neurexin, the other two, itx-1 and nlr-1, are orthologs of the Caspr subfamily of neurexin-like genes. Based on reporter gene analysis, we find that nrx-1 is exclusively expressed in most if not all cells of the nervous system and localizes to presynaptic specializations. itx-1 and nrx-1 reporter genes are expressed in non-overlapping patterns within and outside the nervous system. ITX-1 protein co-localizes with β-G-spectrin to a subapical domain within intestinal cells. These studies provide a starting point for further functional analysis of this family of proteins.
AB - The neurexin superfamily is a group of transmembrane molecules mediating cell-cell contacts and generating specialized membranous domains in polarized epithelial and nerves cells. We describe here the domain organization and expression of the entire, core neurexin superfamily in the nematode Caenorhabditis elegans, which is composed of three family members. One of the superfamily members, nrx-1, is an ortholog of vertebrate neurexin, the other two, itx-1 and nlr-1, are orthologs of the Caspr subfamily of neurexin-like genes. Based on reporter gene analysis, we find that nrx-1 is exclusively expressed in most if not all cells of the nervous system and localizes to presynaptic specializations. itx-1 and nrx-1 reporter genes are expressed in non-overlapping patterns within and outside the nervous system. ITX-1 protein co-localizes with β-G-spectrin to a subapical domain within intestinal cells. These studies provide a starting point for further functional analysis of this family of proteins.
UR - http://www.scopus.com/inward/record.url?scp=79951676867&partnerID=8YFLogxK
U2 - 10.1016/j.gep.2010.10.008
DO - 10.1016/j.gep.2010.10.008
M3 - مقالة
SN - 1567-133X
VL - 11
SP - 144
EP - 150
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 1-2
ER -