The neurexin superfamily of Caenorhabditis elegans

Liat Haklai-Topper, Juergen Soutschek, Helena Sabanay, Jochen Scheel, Oliver Hobert, Elior Peles

Research output: Contribution to journalArticlepeer-review


The neurexin superfamily is a group of transmembrane molecules mediating cell-cell contacts and generating specialized membranous domains in polarized epithelial and nerves cells. We describe here the domain organization and expression of the entire, core neurexin superfamily in the nematode Caenorhabditis elegans, which is composed of three family members. One of the superfamily members, nrx-1, is an ortholog of vertebrate neurexin, the other two, itx-1 and nlr-1, are orthologs of the Caspr subfamily of neurexin-like genes. Based on reporter gene analysis, we find that nrx-1 is exclusively expressed in most if not all cells of the nervous system and localizes to presynaptic specializations. itx-1 and nrx-1 reporter genes are expressed in non-overlapping patterns within and outside the nervous system. ITX-1 protein co-localizes with β-G-spectrin to a subapical domain within intestinal cells. These studies provide a starting point for further functional analysis of this family of proteins.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalGene Expression Patterns
Issue number1-2
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Developmental Biology


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