The N-Degron Pathway Mediates ER-phagy

Chang Hoon Ji; Hee Yeon Kim; Ah Jung Heo; Su Hyun Lee; Min Ju Lee; Su Bin Kim; Ganipisetti Srinivasrao; Su Ran Mun; Hyunjoo Cha-Molstad; Aaron Ciechanover; Cheol Yong Choi; Hee Gu Lee; Bo Yeon Kim; Yong Tae Kwon

doi:10.1016/j.molcel.2019.06.028

The N-Degron Pathway Mediates ER-phagy

Chang Hoon Ji, Hee Yeon Kim, Ah Jung Heo, Su Hyun Lee, Min Ju Lee, Su Bin Kim, Ganipisetti Srinivasrao, Su Ran Mun, Hyunjoo Cha-Molstad, Aaron Ciechanover, Cheol Yong Choi, Hee Gu Lee, Bo Yeon Kim, Yong Tae Kwon

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Ji et al. show that the N-degron pathway mediates ER-phagy for ER protein quality control, initiated by the interaction of the autophagic cargo adaptor p62 and the transmembrane E3 ligase TRIM13. Ubiquitination of TRIM13 and the N-terminal arginine residue of N-degron substrates such as BiP/GRP78 function as ER-phagy degrons.

Original language	English
Pages (from-to)	1058-+
Journal	Molecular Cell
Volume	75
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.06.028
State	Published - 5 Sep 2019

Keywords

ER homeostasis
ER protein quality control
ER stress response
ER-phagy
N-degron pathway
N-terminal arginylation
TRIM13
endoplasmic reticulum
p62
ubiquitination
α1-antitrypsin deficiency

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.06.028

Cite this

@article{c521ff5e79fa498ab0b71bc21d626250,

title = "The N-Degron Pathway Mediates ER-phagy",

abstract = "Ji et al. show that the N-degron pathway mediates ER-phagy for ER protein quality control, initiated by the interaction of the autophagic cargo adaptor p62 and the transmembrane E3 ligase TRIM13. Ubiquitination of TRIM13 and the N-terminal arginine residue of N-degron substrates such as BiP/GRP78 function as ER-phagy degrons.",

keywords = "ER homeostasis, ER protein quality control, ER stress response, ER-phagy, N-degron pathway, N-terminal arginylation, TRIM13, endoplasmic reticulum, p62, ubiquitination, α1-antitrypsin deficiency",

author = "Ji, \{Chang Hoon\} and Kim, \{Hee Yeon\} and Heo, \{Ah Jung\} and Lee, \{Su Hyun\} and Lee, \{Min Ju\} and Kim, \{Su Bin\} and Ganipisetti Srinivasrao and Mun, \{Su Ran\} and Hyunjoo Cha-Molstad and Aaron Ciechanover and Choi, \{Cheol Yong\} and Lee, \{Hee Gu\} and Kim, \{Bo Yeon\} and Kwon, \{Yong Tae\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "5",

doi = "10.1016/j.molcel.2019.06.028",

language = "الإنجليزيّة",

volume = "75",

pages = "1058--+",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

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TY - JOUR

T1 - The N-Degron Pathway Mediates ER-phagy

AU - Ji, Chang Hoon

AU - Kim, Hee Yeon

AU - Heo, Ah Jung

AU - Lee, Su Hyun

AU - Lee, Min Ju

AU - Kim, Su Bin

AU - Srinivasrao, Ganipisetti

AU - Mun, Su Ran

AU - Cha-Molstad, Hyunjoo

AU - Ciechanover, Aaron

AU - Choi, Cheol Yong

AU - Lee, Hee Gu

AU - Kim, Bo Yeon

AU - Kwon, Yong Tae

PY - 2019/9/5

Y1 - 2019/9/5

N2 - Ji et al. show that the N-degron pathway mediates ER-phagy for ER protein quality control, initiated by the interaction of the autophagic cargo adaptor p62 and the transmembrane E3 ligase TRIM13. Ubiquitination of TRIM13 and the N-terminal arginine residue of N-degron substrates such as BiP/GRP78 function as ER-phagy degrons.

AB - Ji et al. show that the N-degron pathway mediates ER-phagy for ER protein quality control, initiated by the interaction of the autophagic cargo adaptor p62 and the transmembrane E3 ligase TRIM13. Ubiquitination of TRIM13 and the N-terminal arginine residue of N-degron substrates such as BiP/GRP78 function as ER-phagy degrons.

KW - ER homeostasis

KW - ER protein quality control

KW - ER stress response

KW - ER-phagy

KW - N-degron pathway

KW - N-terminal arginylation

KW - TRIM13

KW - endoplasmic reticulum

KW - p62

KW - ubiquitination

KW - α1-antitrypsin deficiency

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U2 - 10.1016/j.molcel.2019.06.028

DO - 10.1016/j.molcel.2019.06.028

M3 - مقالة

SN - 1097-2765

VL - 75

SP - 1058-+

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

The N-Degron Pathway Mediates ER-phagy

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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