@article{339851bc048d45ca9d638a9a5b09ba47,
title = "The microbial opsin family of optogenetic tools",
abstract = "The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.",
author = "Feng Zhang and Johannes Vierock and Ofer Yizhar and Fenno, {Lief E.} and Satoshi Tsunoda and Arash Kianianmomeni and Matthias Prigge and Andre Berndt and John Cushman and Juergen Polle and Jon Magnuson and Peter Hegemann and Karl Deisseroth",
note = "NIH [TR01]; Robert Metcalfe; Michael Boylan; McKnight; Gates; Simons; Damon Runyon Foundation; DFG; DOE's Office of Science [DE-AC02-05CH11231]Full funding information for K.D. is listed at http:// www.optogenetics.org/ funding and includes the Gatsby Charitable Foundation and the Keck, Snyder, Woo, and Yu Foundations, as well as CIRM, NIMH, NINDS, NIDA, and the DARPA REPAIR program. F.Z. is supported by the NIH TR01, Robert Metcalfe, Michael Boylan, and the McKnight, Gates, Simons, and Damon Runyon Foundations. L. E. F. is supported by the NIH MSTP program. P. H. is supported by the DFG. We thank the entire Deisseroth laboratory for their support and Dr. Duc Tran for assistance. Genome and transcriptome sequencing and assembly were performed by the Department of Energy (DOE) Joint Genome Institute and supported by the DOE's Office of Science under Contract No. DE-AC02-05CH11231.",
year = "2011",
month = dec,
day = "23",
doi = "10.1016/j.cell.2011.12.004",
language = "الإنجليزيّة",
volume = "147",
pages = "1446--1457",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "7",
}