The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

Efrat Avigad Laron; Emil Aamar; David Enshell-Seijffers

doi:10.1016/j.celrep.2018.06.084

The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

Efrat Avigad Laron
, Emil Aamar
, David Enshell-Seijffers

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.

Original language	English
Pages (from-to)	909-921.e3
Journal	Cell Reports
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2018.06.084
State	Published - 24 Jul 2018

Keywords

dermal papilla
hair follicle
mesenchymal niche
regeneration
stem cell quiescence

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.celrep.2018.06.084

Cite this

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title = "The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells",

abstract = "Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.",

keywords = "dermal papilla, hair follicle, mesenchymal niche, regeneration, stem cell quiescence",

author = "\{Avigad Laron\}, Efrat and Emil Aamar and David Enshell-Seijffers",

note = "Funding Information: This research was funded by the USA-Israel Binational Science Foundation (BSF) (2013375) and the Israel Science Foundation (ISF) (1304/14). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support. Funding Information: This research was funded by the USA-Israel Binational Science Foundation ( BSF ) ( 2013375 ) and the Israel Science Foundation (ISF) ( 1304/14 ). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.",

year = "2018",

month = jul,

day = "24",

doi = "10.1016/j.celrep.2018.06.084",

language = "English",

volume = "24",

pages = "909--921.e3",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

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AU - Avigad Laron, Efrat

AU - Aamar, Emil

AU - Enshell-Seijffers, David

N1 - Funding Information: This research was funded by the USA-Israel Binational Science Foundation (BSF) (2013375) and the Israel Science Foundation (ISF) (1304/14). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support. Funding Information: This research was funded by the USA-Israel Binational Science Foundation ( BSF ) ( 2013375 ) and the Israel Science Foundation (ISF) ( 1304/14 ). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.

PY - 2018/7/24

Y1 - 2018/7/24

N2 - Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.

AB - Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.

KW - dermal papilla

KW - hair follicle

KW - mesenchymal niche

KW - regeneration

KW - stem cell quiescence

UR - https://www.scopus.com/pages/publications/85049726932

U2 - 10.1016/j.celrep.2018.06.084

DO - 10.1016/j.celrep.2018.06.084

M3 - Article

C2 - 30044987

SN - 2211-1247

VL - 24

SP - 909-921.e3

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

Abstract

Keywords

ASJC Scopus subject areas

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