The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

Efrat Avigad Laron, Emil Aamar, David Enshell-Seijffers

Research output: Contribution to journalArticlepeer-review

Abstract

Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.

Original languageEnglish
Pages (from-to)909-921.e3
JournalCell Reports
Volume24
Issue number4
DOIs
StatePublished - 24 Jul 2018

Keywords

  • dermal papilla
  • hair follicle
  • mesenchymal niche
  • regeneration
  • stem cell quiescence

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology

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