TY - JOUR
T1 - The locus of microRNA-10b
T2 - A critical target for breast cancer insurgence and dissemination
AU - Biagioni, Francesca
AU - Ben-Moshe, Noa Bossel
AU - Fontemaggi, Giulia
AU - Yarden, Yosef
AU - Domany, Eytan
AU - Blandino, Giovanni
N1 - AIRC [08/30R/89]; Leir Charitable FoundationWork in Blandino's lab is supported by AIRC grant N (08/30R/89). Work of E Domany and N Bossel Ben-Moshe was supported by the Leir Charitable Foundation.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
AB - Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84881507602&partnerID=8YFLogxK
U2 - https://doi.org/10.4161/cc.25380
DO - https://doi.org/10.4161/cc.25380
M3 - مقالة مرجعية
SN - 1538-4101
VL - 12
SP - 2371
EP - 2375
JO - Cell Cycle
JF - Cell Cycle
IS - 15
ER -