The lipid-binding side of notch ligands

Ben Zion Shilo; David Sprinzak

doi:10.15252/embj.201797621

The lipid-binding side of notch ligands

Ben Zion Shilo, David Sprinzak

Weizmann Institute of Science, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.

Original language	English
Pages (from-to)	2182-2183
Number of pages	2
Journal	EMBO Journal
Volume	36
Issue number	15
DOIs	https://doi.org/10.15252/embj.201797621
State	Published - 1 Aug 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

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10.15252/embj.201797621

Cite this

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AB - Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.

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M3 - مقالة

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JO - EMBO Journal

JF - EMBO Journal

IS - 15

ER -

The lipid-binding side of notch ligands

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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