The lipid-binding side of notch ligands

Ben Zion Shilo, David Sprinzak

Research output: Contribution to journalArticlepeer-review


Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.

Original languageEnglish
Pages (from-to)2182-2183
Number of pages2
JournalEMBO Journal
Issue number15
StatePublished - 1 Aug 2017

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry,Genetics and Molecular Biology
  • Molecular Biology
  • General Neuroscience


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