TY - JOUR
T1 - The intricate nature of senescence in development and cell plasticity
AU - Gal, Hilah
AU - Majewska, Julia
AU - Krizhanovsky, Valery
N1 - V.K. is supported by grants from the European Research Council under Horizon 2020 ( 856487 ), from the Israel Science Foundation ( 634‐15 ; 2633-17 ; 1626-20 ), Israel Ministry of Health, Minerva Center “Aging, from Physical Materials to Human Tissues” and Sagol Institute for Longevity Research .
PY - 2022/12
Y1 - 2022/12
N2 - Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced secretory activity, has functional roles in both physiological and pathological conditions. Although senescence has been linked for a long time with cancer and ageing, recent studies have revealed a functional role of senescence in development, regeneration and reprogramming. Notably, the transient presence of senescent cells may be beneficial, in contrast to the potential deleterious effects of persistent senescence in aged or chronically damaged tissues. We will discuss how senescence contributes to embryonic development, cell plasticity and tissue regeneration, as a highly coordinated and programmed cellular state.
AB - Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced secretory activity, has functional roles in both physiological and pathological conditions. Although senescence has been linked for a long time with cancer and ageing, recent studies have revealed a functional role of senescence in development, regeneration and reprogramming. Notably, the transient presence of senescent cells may be beneficial, in contrast to the potential deleterious effects of persistent senescence in aged or chronically damaged tissues. We will discuss how senescence contributes to embryonic development, cell plasticity and tissue regeneration, as a highly coordinated and programmed cellular state.
U2 - 10.1016/j.semcancer.2021.01.004
DO - 10.1016/j.semcancer.2021.01.004
M3 - مقالة
SN - 1044-579X
VL - 87
SP - 214
EP - 219
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -