The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Itay Koren

doi:https://doi.org/10.1016/j.str.2022.08.003

The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Itay Koren

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Structure, Kampmeyer et al. provide detailed mechanistic insights into how structural changes in disease-associated dihydrofolate reductase (DHFR) missense variants affect their cellular protein abundance and discuss implications for hereditary megaloblastic anemia disease.

Original language	English
Pages (from-to)	1219-1221
Number of pages	3
Journal	Structure
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.str.2022.08.003
State	Published - 1 Sep 2022

All Science Journal Classification (ASJC) codes

Molecular Biology
Structural Biology

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https://doi.org/10.1016/j.str.2022.08.003

Cite this

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title = "The hidden (degron) truth behind the degradation of DHFR disease-associated variants",

abstract = "In this issue of Structure, Kampmeyer et al. provide detailed mechanistic insights into how structural changes in disease-associated dihydrofolate reductase (DHFR) missense variants affect their cellular protein abundance and discuss implications for hereditary megaloblastic anemia disease.",

author = "Itay Koren",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

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day = "1",

doi = "https://doi.org/10.1016/j.str.2022.08.003",

language = "الإنجليزيّة",

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AB - In this issue of Structure, Kampmeyer et al. provide detailed mechanistic insights into how structural changes in disease-associated dihydrofolate reductase (DHFR) missense variants affect their cellular protein abundance and discuss implications for hereditary megaloblastic anemia disease.

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M3 - تعليقَ / نقاش

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VL - 30

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JO - Structure

JF - Structure

IS - 9

ER -

The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Abstract

All Science Journal Classification (ASJC) codes

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