The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Eran Kotler; Eran Segal

doi:10.1016/j.cell.2018.10.034

The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Eran Kotler, Eran Segal

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

Original language	English
Pages (from-to)	902-904
Number of pages	3
Journal	Cell
Volume	175
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2018.10.034
State	Published - 1 Nov 2018

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2018.10.034

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title = "The Helix Twist: Damage and Repair Follows the DNA Minor Groove",

abstract = "Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.",

author = "Eran Kotler and Eran Segal",

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AU - Segal, Eran

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N2 - Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

AB - Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

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U2 - 10.1016/j.cell.2018.10.034

DO - 10.1016/j.cell.2018.10.034

M3 - مقالة مرجعية

SN - 0092-8674

VL - 175

SP - 902

EP - 904

JO - Cell

JF - Cell

IS - 4

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The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Abstract

All Science Journal Classification (ASJC) codes

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