The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Eran Kotler; Eran Segal

doi:https://doi.org/10.1016/j.cell.2018.10.034

The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Eran Kotler, Eran Segal

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

Original language	English
Pages (from-to)	902-904
Number of pages	3
Journal	Cell
Volume	175
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2018.10.034
State	Published - 1 Nov 2018

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

https://doi.org/10.1016/j.cell.2018.10.034

Cite this

@article{854146c616924d8f90e93259840773a9,

title = "The Helix Twist: Damage and Repair Follows the DNA Minor Groove",

abstract = "Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.",

author = "Eran Kotler and Eran Segal",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = nov,

day = "1",

doi = "https://doi.org/10.1016/j.cell.2018.10.034",

language = "الإنجليزيّة",

volume = "175",

pages = "902--904",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - The Helix Twist

T2 - Damage and Repair Follows the DNA Minor Groove

AU - Kotler, Eran

AU - Segal, Eran

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

AB - Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

UR - http://www.scopus.com/inward/record.url?scp=85055104373&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.cell.2018.10.034

DO - https://doi.org/10.1016/j.cell.2018.10.034

M3 - مقالة مرجعية

SN - 0092-8674

VL - 175

SP - 902

EP - 904

JO - Cell

JF - Cell

IS - 4

ER -

The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this