The grammar of transcriptional regulation

Shira Weingarten-Gabbay, Eran Segal

Research output: Contribution to journalReview articlepeer-review

Abstract

Eukaryotes employ combinatorial strategies to generate a variety of expression patterns from a relatively small set of regulatory DNA elements. As in any other language, deciphering the mapping between DNA and expression requires an understanding of the set of rules that govern basic principles in transcriptional regulation, the functional elements involved, and the ways in which they combine to orchestrate a transcriptional output. Here, we review the current understanding of various grammatical rules, including the effect on expression of the number of transcription factor binding sites, their location, orientation, affinity and activity; co-association with different factors; and intrinsic nucleosome organization. We review different methods that are used to study the grammar of transcription regulation, highlight gaps in current understanding, and discuss how recent technological advances may be utilized to bridge them.

Original languageEnglish
Pages (from-to)701-711
Number of pages11
JournalHuman Genetics
Volume133
Issue number6
DOIs
StatePublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Fingerprint

Dive into the research topics of 'The grammar of transcriptional regulation'. Together they form a unique fingerprint.

Cite this