The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication

Sonja C.J.H. Chua, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Siang Ling Tan, Hui Qing Tan, Hong Meng Lim, David Engelberg, Lina H.K. Lim

Research output: Contribution to journalArticlepeer-review

Abstract

IMPORTANCE: Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.

Original languageAmerican English
Pages (from-to)e0260923
JournalMicrobiology spectrum
Volume12
Issue number1
DOIs
StatePublished - 11 Jan 2024

Keywords

  • COPII
  • H1N1
  • H3N2
  • Sec13
  • influenza
  • non-structural protein 1 (NS1)

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Genetics
  • Physiology
  • Cell Biology
  • Ecology

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