The Emerging Roles of LIS1 Biomechanics in Cellular and Cortical Homeostasis

Aditya Kshirsagar, Orly Reiner

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


LIS1 (LISSENCEPHALY-1, also known as PAFAH1B1) is the first gene identified and reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 is vital in regulating the critical retrograde molecular motor, cytoplasmic dynein. Recent studies show that LIS1 is an essential protein interacting with numerous others, including many RNA-interacting proteins. These findings position LIS1 as a critical hub protein involved in pleiotropic traits. This chapter will discuss how LIS1 can participate in diverse processes, from basic RNA biology to biomechanics regulation, and how its malfunction may contribute to the pathophysiology of various CNS diseases.

Original languageEnglish
Title of host publicationNeocortical Neurogenesis in Development and Evolution
EditorsWieland Huttner
Number of pages32
ISBN (Electronic)9781119819820
ISBN (Print)9781119860808
StatePublished - 1 Jan 2023

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Medicine


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