The Emerging Roles of LIS1 Biomechanics in Cellular and Cortical Homeostasis

Aditya Kshirsagar; Orly Reiner

doi:https://doi.org/10.1002/9781119860914.ch18

The Emerging Roles of LIS1 Biomechanics in Cellular and Cortical Homeostasis

Aditya Kshirsagar, Orly Reiner

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

LIS1 (LISSENCEPHALY-1, also known as PAFAH1B1) is the first gene identified and reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 is vital in regulating the critical retrograde molecular motor, cytoplasmic dynein. Recent studies show that LIS1 is an essential protein interacting with numerous others, including many RNA-interacting proteins. These findings position LIS1 as a critical hub protein involved in pleiotropic traits. This chapter will discuss how LIS1 can participate in diverse processes, from basic RNA biology to biomechanics regulation, and how its malfunction may contribute to the pathophysiology of various CNS diseases.

Original language	English
Title of host publication	Neocortical Neurogenesis in Development and Evolution
Editors	Wieland Huttner
Publisher	Wiley-Hindawi
Chapter	18
Pages	365-396
Number of pages	32
ISBN (Electronic)	9781119819820
ISBN (Print)	9781119860808
DOIs	https://doi.org/10.1002/9781119860914.ch18
State	Published - 1 Jan 2023

All Science Journal Classification (ASJC) codes

General Neuroscience
General Medicine

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abstract = "LIS1 (LISSENCEPHALY-1, also known as PAFAH1B1) is the first gene identified and reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 is vital in regulating the critical retrograde molecular motor, cytoplasmic dynein. Recent studies show that LIS1 is an essential protein interacting with numerous others, including many RNA-interacting proteins. These findings position LIS1 as a critical hub protein involved in pleiotropic traits. This chapter will discuss how LIS1 can participate in diverse processes, from basic RNA biology to biomechanics regulation, and how its malfunction may contribute to the pathophysiology of various CNS diseases.",

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AB - LIS1 (LISSENCEPHALY-1, also known as PAFAH1B1) is the first gene identified and reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 is vital in regulating the critical retrograde molecular motor, cytoplasmic dynein. Recent studies show that LIS1 is an essential protein interacting with numerous others, including many RNA-interacting proteins. These findings position LIS1 as a critical hub protein involved in pleiotropic traits. This chapter will discuss how LIS1 can participate in diverse processes, from basic RNA biology to biomechanics regulation, and how its malfunction may contribute to the pathophysiology of various CNS diseases.

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The Emerging Roles of LIS1 Biomechanics in Cellular and Cortical Homeostasis

Abstract

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