The effect of end-group substitution on surface self-assembly of peptides

Alona Dolid, Meital Reches

Research output: Contribution to journalArticlepeer-review


Biofouling, the undesirable accumulation of organisms onto surfaces, affects many areas including health, water, and energy. We previously designed a tripeptide that self-assembles into a coating that prevents biofouling. The peptide comprises three amino acids: DOPA, which allows its adhesion to the surface, and two fluorinated phenylalanine residues that direct its self-assembly into a coating and acquire it with antifouling properties. This short peptide has an ester group at its C-terminus. To examine the importance of this end group for the self-assembly and antifouling properties of the peptide, we synthesized and characterized tripeptides with different end groups (ester, amide, or carboxylic group). Our results indicate that different groups at the C-terminus of the peptide can lead to a change in the peptide assembly on the surface and its adsorption process. However, this change only affects the antifouling properties of the coating toward Gram-positive bacteria (Staphylococcus epidermidis), whereas Gram-negative bacteria (Escherichia coli) are not affected.

Original languageAmerican English
Article numbere3212
JournalJournal of Peptide Science
Issue number10
StatePublished - 1 Oct 2019


  • antifouling
  • biofouling
  • end group
  • peptide
  • self-assembly

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


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