The complex nature of fragile site plasticity and its importance in cancer

Dan Sarni; Batsheva Kerem

doi:10.1016/j.ceb.2016.03.017

The complex nature of fragile site plasticity and its importance in cancer

Dan Sarni, Batsheva Kerem

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.

Original language	English
Pages (from-to)	131-136
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	40
DOIs	https://doi.org/10.1016/j.ceb.2016.03.017
State	Published - 1 Jun 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/j.ceb.2016.03.017

Cite this

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abstract = "Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.",

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AB - Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.

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The complex nature of fragile site plasticity and its importance in cancer

Abstract

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