TY - JOUR
T1 - The Circadian Nature of Mitochondrial Biology
AU - Manella, Gal
AU - Asher, Gad
N1 - Israel Science Foundation [ISF 138/12]; European Research Council [ERC-2011 METACYCLES 310320]; EMBO We apologize to all colleagues whose work could not be cited due to space limitations. We are grateful to R. Aviram for her valuable comments on the manuscript. GA is supported by the Israel Science Foundation (ISF 138/12), the European Research Council (ERC-2011 METACYCLES 310320). GA is recipient of the EMBO young investigator award and incumbent of the Pauline Recanati career development chair.
PY - 2016/12/19
Y1 - 2016/12/19
N2 - Circadian clocks orchestrate the daily changes in physiology and behavior of light-sensitive organisms. These clocks measure about 24 h and tick in a self-sustained and cell-autonomous manner. Mounting evidence points toward a tight intertwining between circadian clocks and metabolism. Although various aspects of circadian control of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial function is rudimentary. In this review, we will survey the current literature related to the circadian nature of mitochondrial biology: from mitochondrial omics studies (e.g., proteome, acetylome, and lipidome), through dissection of mitochondrial morphology, to analyses of mitochondrial processes such as nutrient utilization and respiration. We will describe potential mechanisms that are implicated in circadian regulation of mitochondrial functions in mammals and discuss the possibility of a mitochondrial-autonomous oscillator.
AB - Circadian clocks orchestrate the daily changes in physiology and behavior of light-sensitive organisms. These clocks measure about 24 h and tick in a self-sustained and cell-autonomous manner. Mounting evidence points toward a tight intertwining between circadian clocks and metabolism. Although various aspects of circadian control of metabolic functions have been extensively studied, our knowledge regarding circadian mitochondrial function is rudimentary. In this review, we will survey the current literature related to the circadian nature of mitochondrial biology: from mitochondrial omics studies (e.g., proteome, acetylome, and lipidome), through dissection of mitochondrial morphology, to analyses of mitochondrial processes such as nutrient utilization and respiration. We will describe potential mechanisms that are implicated in circadian regulation of mitochondrial functions in mammals and discuss the possibility of a mitochondrial-autonomous oscillator.
UR - http://www.scopus.com/inward/record.url?scp=85017107438&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fendo.2016.00162
DO - https://doi.org/10.3389/fendo.2016.00162
M3 - مقالة مرجعية
SN - 1664-2392
VL - 7
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 162
ER -