The chromatin roots of abnormal splicing in autism

Eden Engal; Mai Baker; Maayan Salton

doi:10.1016/j.tig.2022.06.001

The chromatin roots of abnormal splicing in autism

Eden Engal, Mai Baker, Maayan Salton

Department of Biochemistry and Molecular Biology

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.

Original language	English
Pages (from-to)	892-894
Number of pages	3
Journal	Trends in Genetics
Volume	38
Issue number	9
DOIs	https://doi.org/10.1016/j.tig.2022.06.001
State	Published - Sep 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

autism spectrum disorder
chromatin
pre-mRNA splicing
splicing regulation

All Science Journal Classification (ASJC) codes

Genetics

Access to Document

10.1016/j.tig.2022.06.001

Cite this

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title = "The chromatin roots of abnormal splicing in autism",

abstract = "Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.",

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AU - Engal, Eden

AU - Baker, Mai

AU - Salton, Maayan

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AB - Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.

KW - autism spectrum disorder

KW - chromatin

KW - pre-mRNA splicing

KW - splicing regulation

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U2 - 10.1016/j.tig.2022.06.001

DO - 10.1016/j.tig.2022.06.001

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JO - Trends in Genetics

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The chromatin roots of abnormal splicing in autism

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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